The rising global burden of nutrition-related diseases[1] calls for concerted action. There is an emerging urgent need to resolve acute and chronic hunger, malnutrition, and undernutrition[2]. In particular, compromised nutritional status of mothers and children very early in life has significant impact on the future occurrence of chronic diseases such as heart disease and type 2 diabetes[3, 4]. Concurrently, populations are faced with increasing implications of overweight and obesity. The World Health Organization (WHO) estimates that in 2005, more than 1 billion people were overweight and 300 million obese, with projections of 1.5 billion people overweight by 2015[1]. Worldwide, 44 percent of diabetes burden, 23 percent of ischemic heart disease burden, and 7 to 41 percent of the burden of some cancers can be attributed to overweight and obesity[5].

This paper reviews the progress that major food manufacturing companies and partnerships are making in nutrition-related health, especially in regard to overweight and obesity. Using PepsiCo as an example of one company, specific steps are outlined that will transform PepsiCo's product portfolio and how nutritional choices are communicated to customers. Also indicated are a number of constraints that hamper more rapid progress. Throughout, it is argued that further progress in chronic disease prevention depends on collaborations across multiple sectors, from agriculture to retailers and private to public, for effective development and distribution of packaged food.

Some food companies have independently taken steps to change the nutrition composition of their portfolios. ConAgra Foods announced in October 2009 that it will reduce sodium by an average of 20 percent in roughly 80 percent of its products by the year 2015. In fact, by summer 2011 the company's Chef Boyardee canned pasta will have decreased its sodium by about 35 percent over five years[10]. In March 2010, Kraft Foods also revealed plans to reduce sodium in its North American products by an average of 10 percent by 2012[11].

Shortly after assuming office as the new CEO of PepsiCo, Indra Nooyi announced in 2007 that the company would increasingly address the non-financial aspects of its performance. The phrase "performance with purpose" (PwP) means delivering sustainable growth through investments in the environment, health and nutrition (human sustainability), and the workforce. Larry Thompson, PepsiCo's Legal Counsel has argued that PwP is a business imperative and critical to the long-term growth of companies. He has emphasized the need for corporations to always take the long view in considering their policies and actions[L. Thompson, personal communication, March 21, 2010].

PepsiCo's global nutrition criteria build on the concepts of "nutrients to limit" and "nutrients and food groups to encourage," and serve as the practical translation of nutrition science and dietary recommendations for marketers and food and beverage developers. "Nutrients to limit" are those of public health concern when consumed in excess and include reduction efforts on sodium, saturated fat and sugar intake. "Nutrients and food groups to encourage" are based on regional nutritional needs, including those related to micronutrient deficiencies and essential fatty acids requirements. Greater attention is being given to increasing the nutritional quality of the PepsiCo portfolio by expanding product offerings that include nuts, wholegrain, vegetables and fruits.

Only the commitments related to human sustainability are given here. Complementary goals related to the environment include specific targets for energy and water use, recycling, soil conservation, local sourcing from farmers, and reducing the carbon footprint of products. One goal is shared between the PepsiCo environment and human pillars: "integrating...policies and actions on human health, agriculture and the environment to make sure they support each other." Turning this goal into action involves developing health and environmental impact assessment methods to be applied to new products and processes under development.

Many recommendations to food companies regarded as simple have turned out to be complex, requiring deeper insights into the limitations of science, the role of supply chains and commodity prices, farmers, retailers, and of consumer behavior[11]. For instance, there have been calls for food companies to lower the level of saturated fats in the oils they use as a means of reducing cardiovascular disease risks. Implementation of such a call is not easy. With the price of palm oil relatively cheap, customer affordability makes it more difficult to build a case for use of alternative oils with improved fatty acid profiles. Further, the inherent productivity of palm versus sunflower and other oilseeds favors palm. Sudden switches from one oil to another oil in a manufacturing process is unrealistic and in many instances, undesirable. Rather, a well-structured long-term plan is required and includes investing in a range of oils that can meet large scale supply demands, supporting research to reduce the saturated fat levels of commonly used edible oils, reviewing pricing and subsidies for oils, and shifting palm oil use from unsustainable to certified sustainable sources. The recent announcement by Unilever to distance itself from a major palm-oil producer discovered to be clearing protected rainforest is a positive case study of such change[15]. Building a future supply of more suitable oils is especially important in countries like China and India where consumption has soared in recent decades[14].

Food companies face challenges outside of their control that influence their ability to design more food and beverage choices that contribute to healthier eating and drinking. Global environmental changes will affect crop availability: India's weakest monsoon in almost four decades has damaged rice and oilseed crops, while cold weather and drought in China may shrink soybean and corn harvests[16]. These environmental disruptions will impact the cost of commodities. In sub-Saharan Africa, all countries surveyed by FAO reported higher domestic rice prices in 2009 than 2008, while 89 percent reported higher prices for maize, millet, and sorghum[17]. Continued environmental pressures, increased global consumption, and the use of crops such as corn and soybean for alternative fuels will continue to hamper the efforts of food suppliers. There is also concern that the amount of meat consumed in developing countries is growing - in the past year, growth has been three times higher than in developed countries[18]. Meat-based diets require more energy, land, and water resources than vegetarian, meaning that the rise of meat consumption will exacerbate resource scarcity for grain and crop production[19].

A further constraint in improving global nutrition is the lack of capacity in nutrition science. Emerging economies are beset by dual burdens of under- and over-nutrition crises. The human capacity to address these needs is weak, and evident when studying nutrition output from researchers. The proportion of full-length publications in leading science and medical journals (based on citation indexes) by country of the first author, nutrition topic, and year was examined from 1991-2007. For the last 2 years, only about 5% of first authors for any nutrition category were from India or China - two countries that account for 40% of the world's population[20]. This weak public sector nutrition science creates serious obstacles for corporate innovation.

Greater R&D intensity is one route to the disruptive innovation critically needed in the food industry. R&D intensity is a well-established indicator of industry innovation[21]. The pharmaceutical and biotechnology industry has consistently ranked highest for several years by this indicator (spending about 15-20% of sales on R&D), while the food industry is typically among the lowest spenders at 1-2% of sales[22]. Even among government institutions the exact total percentage spent on food-based solutions, while hard to calculate is likely to be small. The National Institutes of Health (NIH) holds the majority of US government research spending on nutrition and obesity at roughly 1.4 billion and 700 million, respectively. They fall short of the levels provided for research related to infectious and emerging infectious diseases, bioengineering, and others[23]. Further, the major outcomes of NIH nutrition and obesity research often lead to new medication or surgical solutions as opposed to sustainable food-based solutions. This mismatch between where R&D resources are spent contrasts with recommendations of a global and diverse set of experts who have identified the top 20 policy and research priorities for chronic diseases[24], a number of which involve food and nutrition policy. A significant increase in publicly financed research into food- and lifestyle-based solutions to chronic diseases would stimulate innovation among private and public researchers and implementers.

Achieving product goals requires a considerably increased investment in research, close interaction with those working on agricultural commodities, and deeper insights into how future consumers will respond to healthier products. Some consumers are concerned about having to compromise taste for better health, to pay more, or to give up something to which they are accustomed. Public health has tended to undervalue consumer insights and taste preferences in promoting healthy eating[27].

Questions of consumer preference, as well as examples of complexity mentioned in earlier sections of this article, are not presented as reasons for delay or inaction. Rather they are discussed because of the authors' own experiences in the public health sector (note that GM worked at the CDC, MK the Mayo Clinic, and DY at WHO) that by openly highlighting the roadblocks companies face in delivering a healthier portfolio, colleagues in the public sector will be encouraged to partner in finding solutions.

Recognition of the potential for well-constructed private-public alliances to address chronic disease has been growing over the last year. At the World Economic Forum meeting in Dubai in November 2009, the Global Agenda Council for chronic diseases, which includes representation from the private and public sectors, proposed development of an "Action Coalition" to stimulate joint action and promote policy coherence across sectors and businesses. The coalition will collaborate with WHO's Global Non-communicable Disease (NCD) Network, supporting the implementation of the WHO NCD Action Plan. At the latest meeting of NCD-Net, the WHO Director General and Klaus Schwab, Executive Chairman of the WEF expressed their strongest support for such actions to be expedited.

An IOM 2010 report focused on reducing the global burden of cardiovascular disease stated: "many intervention approaches ...are more likely to succeed if public education and government policies and regulations are complemented by the voluntary collaboration of the private sector[30]." Specifically, it was suggested that the food industry increase international collaborations aiming to reduce unhealthy ingredients while also placing restrictions on marketing of unhealthy products. These recommendations support the creation of more private-public alliances and are in agreement with the steps that food companies are already taking to address chronic disease.

The progress and goals reported here provide a platform for accelerated actions that could have major positive implications for public health.

DY played a role in steering the consultative process for the CEO meetings under Gro Harlaem Brundtland while then at WHO.