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Table 1 Study characteristics: location, study design and economic perspective

From: Evidence for cost-effectiveness of lifestyle primary preventions for cardiovascular disease in the Asia-Pacific Region: a systematic review

Study

Country/baseline year

Intervention length

Follow-up

Study population

Key intervention components

Control

Perspective (e.g. health sector)

Amarasinghe[30]

Australia, 2006

1 Year

1 Year

18 yrs+in Western Australia, male and female, CVD risk level unknown

GP advice for sufficient physical activity (150+ minutes/week) upon random presentation at clinic (6 visits)

No GP advice on physical activity

Health Sector

Cecchini[31]

China, India, 2008

Lifetime of population at baseline or up to 100 yrs

Lifetime

Whole population

Int1 Worksite health promotion; Int2 Compulsory food labelling; Int3 Mass media health promotion campaigns; Int4 Fiscal measures affecting fruit and vegetable and food high in fat

No intervention

Health sector

Cobiac[32]

Australia, 2003

Lifetime of population at baseline or up to 100 yrs

Lifetime

Whole population (15+ yrs)

Int1 Volumetric taxation; Int2 Advertising bans; Int3 Licensing controls on operating hours; Int4 Brief intervention by GP; Int 5 Brief intervention by GP with GP telemarketing and support; Int6 Residential treatment; Int7 Increase legal age; Int8 Drink driving campaigns.

Current best practice/'do nothing' (random breath testing present)

Health sector

Cobiac[33]

Australia, 2003

Lifetime of population at baseline

6 Months

Whole population (adult, BMI 25 kg/m2, don’t eat at least 7 serves of fruit and vegetables/day, don’t get 30+ minutes moderate exercise at least 5x/week)

Int1 Lighten up (group counselling for changing physical activity and nutrition patterns); Int2 Weight watchers (low-calorie diet and physical activity advice)

No intervention

Health sector

Cobiac[34]

Australia, 2003

Lifetime of population at baseline

Lifetime

Whole population (15+ yrs at baseline)

Int1 Pedometers; Int2 Mass media campaign; Int3 Internet advertising; Int4 GP physical activity prescription program; Int5 Travel smart program to encourage use of active transport; Int6 GP referral to exercise physiologist.

Current practice

Societal and health sectors

Cobiac[35]

Australia, 2003

Lifetime of population at baseline

Lifetime

Whole population (30 + yrs at baseline)

Int1 Govt. incentives for moderate reduction in salt in processed foods by manufacturers and product labelling (voluntary); Int2 Govt. mandate to moderate salt limits in processed foods; Int3 Dietary advice for those at increased risk of CVD; Int4 Dietary advice for those at high risk of CVD

No intervention

Health sector

Cobiac[36]

Australia, 2003

Lifetime of population at baseline

Lifetime

Whole adult population

Int1 Community-based events, sponsorship, promotion; Int2 Information mail-out (multiple re-tailored); Int3 Information mail-out (multiple tailored); Int4 Information mail-out (tailored); Int5 Individual and group dietary counselling; Int6 Individual dietary counselling; Int7 Telephone counselling and information mail-out

No intervention

Health sector

Cobiac[37]

Australia, 2008

Lifetime of population at baseline

Lifetime

Whole population (35-84 yrs at baseline, never experienced heart disease or stroke, all CVD risk levels)

Community: Int1 Heart health program; Int2 Mandatory reduction of salt in manufacture of bread, cereals and margarines. Individual: Int3 Dietary advice from doctor or dietician; Int4 Referral to more intensive lifestyle program with specialised counselling (≥15% risk of CVD); Int5 Advice from doctor to switch to phytosterol enriched margarine (≥15% risk of CVD)

Current best practice (‘do nothing’)

Health sector

Dalziel[38]

Australia, 2003

6 Months - 6 Years

1 session -1 Year

Unclear - clinical trials were in adults

8 dietary interventions

No intervention

Societal perspective

Dalziel[39]

New Zealand, 2000

Lifetime (40 years)

1 Year

Adults 40-79 yrs, M&F, not getting 2.5 hrs physical activity per week (n = 878)

Physical activity counselling program (verbal advice and written exercise program by GP or Nurse and telephone exercise specialist follow-up)

Best practice

Health Sector

Elley[40]

New Zealand, 2000

1 Year

3 Months

Adults 40-79 yrs, M&F, not getting 2.5 hrs physical activity per week (n = 878)

Physical activity counselling program (verbal advice and written exercise program by GP or Nurse and telephone exercise specialist follow-up)

Best practice

Programme funder Perspective

Forster[41]

Australia, 2003

Lifetime of population at baseline or 100 yrs

6-12 Months

Adults 20 yrs + overweight and obese

Int1:Hypertension diet with exercise; Int2:Low-fat diet

No intervention

Health sector

Ha[42]

Vietnam, 2007

Lifetime of population at baseline or up to 100 yrs

10 Years

Adult population 30 + years at baseline, all risk levels

Int1: Reduction in salt intake through voluntary manufacturer limits, mass media campaign; Int2:Mass media campaign to reduce cholesterol; Int3:Mass media campaign to reduce tobacco; Int4:Interventions 1-3 combined

No intervention

Health sector

Higashi[43]

Vietnam, 2006

Lifetime of population at baseline

1 Session

Adult population 15 + y at baseline, stratified by i) never smoker, ii) current smoker, iii) ex-smoker

Brief physician advice (GP or other health professional) on tobacco cessation (1 min screening and 8 min advice session)

Pharmaceutical intervention (NRT patch, NRT gum, Bupropion, Varenicline)

Health sector

Higashi[44]

Vietnam, 2006

Lifetime of population at baseline

1-10 Years

Adult population 15 + yr at baseline, all risk levels

Int1: Excise tax increase (55-65%); Int2: Excise tax increase (55-75%); Int3: Excise tax increase (55-85%); Int4: Graphic warning labels on cigarette packs; Int5: Mass media campaigns; Int6: Smoking bans in public; Int7: Smoking bans in workplace. All enforced for 10 years.

No intervention

Government perspective (including initial investment in interventions)

Jafar[45]

Pakistan, 2007

2 years

2 Years

Adult male and females 40 + years, hypertensive

Home health education (HHE) and training of GPs on BP control - Int1 :HHE + trained GP; Int2 :HHE; Int3 : Trained GP

Current practice

Societal

Joo[46]

South Korea, 2007

12 weeks

12 Weeks

Adults 20-64 yrs, BMI ≥ 25 kg/m2, waist circumference >90 cm men, 85 cm women, 30 min exercise 4 times/week

Protein-rich oriental diet and either of:- Int1: Public health centre behavioural program; Int2 : Remote behavioural program (internet, SMS)

None

Program funder perspective

Murray[47]

South East Asia Region (Indonesia, Sri Lanka, Thailand, Bangladesh, Bhutan, Dem Peop. Rep. Korea, India, Maldives, Myanmar, Nepal), 2000

Lifetime of population at baseline or 100 years

Lifetime

Whole population

Population interventions for BP and cholesterol control: Int1:Voluntary agreements on salt content with manufacturers; Int2:Legislated salt limits in manufactured food; Int3:Mass media campaign; Int4 : Int2 + Int3

Current practice

Government (implementation and health sector costs)

Navarro[48]

Australia, 2005

1 year

1 Session

Adults 18 + yrs at baseline from 10 rural communities in NSW, stratified by drinking behaviour

GP screening and brief intervention (1 session)

Current best practice

Health sector

Oldenburg[25]

Australia, 1990

1 year

1 Year

Adult male and female ambulance officers and paramedics

Int1:Health risk assessment (4x over 12 months); Int2 : Risk factor education (4x over 12 months plus reading material); Int3 : Behavioural counselling (risk factor education plus 1 session behavioural counselling); Int 4:Behavioural counselling plus financial incentives

No intervention

Program funder perspective

Ortegon[49]

South East Asia Region (Bangladesh, Bhutan, Dem. People’s Republic of Korea, India, Maldives, Myanmar, Nepal), 2005

Lifetime of population at baseline or up to 100 yrs

10 Years

Whole population 15 yrs+

Interventions implemented for 10 years

No Intervention

Program funder and health sector

Int1: Taxes on tobacco (current excise taxation of 40%); Int2:Raise taxes on tobacco (increased excise taxation to 60%); Int3:Enforce bans on tobacco advertising; Int4:Clean indoor air in public places through legislation and enforcement; Int5:Warning labels on cigarette packs; Int6:Brief advice to help quit; Int7:Counselling to help quit; Int8: Voluntary reduction in salt in industry (15%); Int9: Legislated reduction in salt in industry (30%); Int10:Mass media education on BMI and cholesterol

Pritchard[28]

Australia, 1992

1 year

1 Year

25-65 yr old men and women with one or more of: overweight, hypertension, type 2 Diabetes mellitus

6 sessions of counselling on good nutrition and exercise by: Int1: Doctor/dietician; Int2: Dietician only

No counselling

Program funder

Ranson[29]

East Asia & Pacific, South Asia, 1995

Lifetime of participants at baseline

Lifetime

Smokers 15 + years

Public policy control interventions: Int1: 10% price increase; Int2 :Non-price increase, non-pharmaceutical (e.g. mass media)

‘Do nothing’

Program funder (public sector)

Sacks[50]

Australia, 2003

Lifetime of participants at baseline

Lifetime

Whole population 20 years at baseline

Int1: Traffic light labelling of food based on nutritional content; Int2 :Junk food tax (10% rise in prices for consumers)

No intervention

Health sector (with some industry costs included)

Salkeld[27]

Australia, 1990

Lifetime of participants at baseline

1 Year

Male and female, selected by GP for at risk of CVD

Int1:Video intervention for lifestyle behaviours (n = 270); Int2:Video + self-help booklet (n = 232)

Routine care (n = 255)

Health sector (govt.)

Shearer[51]

Australia, 2003

6 months

6 Months

Whole adult population, smokers

Int1:Brief advice by health professional (2x 10 min visits); Int2:Telephone counselling (4x 10 min calls)

No intervention

Program funder (govt.)

Snowdon[52]

Fiji, Tonga, 2006

Lifetime

Lifetime

Whole population

Policy changes around food price, storage, manufacture, items available for consumption

‘Do nothing’

Govt. (cost offsets excluded)

Zomer[53]

Australia, 2012

10 years or death of baseline population

10 Years

10,000 adults 25 yrs with hypertension and metabolic syndrome, no CVD history (based on subsection of AusDiab Study participants)

Daily consumption of dark chocolate (500-1000 mg/day)

No dark chocolate consumption

Health sector

  1. Abbreviations: Int Intervention, CVD Cardiovascular Disease, GP General Practitioner, NRT Nicotine Replacement Therapy, HHE Home Health Education, BMI Body Mass Index, Govt Government.