Results of the systematic review embedded in the mHealth strategies framework to address health systems challenges to non-communicable disease care. Legend. The chronic disease continuum includes healthy people with no apparent disease through patients with complications of non-communicable diseases (NCDs). Health System Challenges (HSC) one through six are shown alongside examples of specific barriers as they relate to NCDs. The mHealth programs found in the literature search are displayed where these programs intersect HSCs at points along the chronic disease continuum. There remain many opportunities for implementation of mHealth for non-communicable diseases (NCDs) in sub-Saharan Africa and other LMIC regions broadly.