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Table 2 Top 20 leading pharmaceutical companies’ innovation activities by therapeutic use

From: Disease burden metrics and the innovations of leading pharmaceutical companies: a global and regional comparative study

Classification of therapeutic usea Top 20 companies’ innovation activitiesb
(Number of drugs (%))
Alimentary tract and metabolism (A class) 404 (12.6)
Blood and blood forming organs (B class) 95 (3)
Cardiovascular system (C class) 151 (4.7)
Dermatologicals (D class) 144 (4.5)
Genito-urinary system and sex hormones (G class) 103 (3.2)
Systemic hormonal preparations (excl. Sex hormones) (H class) 21 (0.7)
General anti-infectives systemic (J class) 286 (8.9)
Antineoplastic and immunomodulating agents (L class) 1008 (31.4)
Musculo-skeletal system (M class) 144 (4.5)
Central nervous system (N class) 366 (11.4)
Parasitology (P class) 19 (0.6)
Respiratory system (R class) 162 (5)
Sensory organs (S class) 84 (2.6)
Diagnostic agents (T class) 21 (0.7)
Various (V class) 207 (6.4)
  1. aClassified based on the EPhMRA classification system
  2. bMultiple counting was allowed for drugs which have several therapeutic uses, and there were assigned more than one class