Author and year | Study setting (Country) | Aim | Study design | Population (n) | Mean/Age range of participants | Percentage of males | Percentage of females | Health systems factors that impact on delay in timely lung cancer diagnosis | Relevant findings |
---|---|---|---|---|---|---|---|---|---|
Abrao, F. C. and 2017 [33] | Brazil | To evaluate the access of patients with lung cancer in a densely populated area of São Paulo to the Brazilian Public Health System, focusing on the time spent from symptom onset or initial diagnosis until the beginning of treatment. | Retrospective study | 509 | 62.50 years | 57.8% | 42.2% | Long waiting times and health system’s incapacity to absorb all patients. | Diagnosis is faster when the patient can make an appointment with a specialist |
Chandra, Subhash and 2009 [34] | India | To determine the average time period required at various steps for diagnosing lung cancer from the onset of symptoms at a tertiary referral centre in Northern India | Retrospective study | 165 | 53 years and older | 84.2% | 15.8% | High cost and inaccessibility of diagnostic investigations such as CT scan, chemotherapy, broncoscopy and long waiting periods | Inappropriate treatment with ATT significantly prolongs delay |
Chatterjee, Surajit and 2016 [35] | India | To summarize the contributing factors in delaying diagnosis of lung cancer for our better knowledge. | Observational cross-sectional | 50 | 55.50 years | 72.0% | 28.0% | High cost and limited availability of CT thorax and long waiting times | Patients were not advised on CT thorax at appropriate time and instead received ATT causing referral delay |
Fernandez de la Vega, J. F. and 2015 [35] | Cuba | To Assess diagnostic delay of lung cancer in patients at the JoaquÃn Albarrán Clinical-Surgical Teaching Hospital, Havana, Cuba, from 2007 to 2010. | Retrospective study | 54 | 51–60 years | 74.1% | 25.9% | Lack of diagnostic tools for imaging, endoscopy and pathology, lack of suitable lung cancer protocol, poor organization and management of health services. | Patients who went directly to hospital did not benefit from shorter delay in diagnosis |
Hsieh, Vivian Chia-Rong and 2012 [25] | Taiwan | To understand the delay in the diagnosis of lung cancer under the healthcare system in Taiwan, and to identify the factors associated with it. | Descriptive analysis | 840 | 62.68 years | 55.9% | 44.1% | Misinterpretation of a chest CT scan, high cost of CT scan and delays due to multiple medical visits. | Delays increase as number of doctors or visits increase |
Ramachandran, Krishnappriya and 2016 [40] | India | To assess physician related delays in the diagnosis of lung cancer and the treatments given before presenting to our center. | Prospective study | 96 | Not specified | Not specified | Not specified | Lung cancer was misdiagnosed as TB and treated with ATT, inadequacy of medical services, delay in referrals and in the performance of subsidiary tests. | Many physicians have a low index of suspicion to diagnose lung malignancy and most commonly misdiagnose it as tuberculosis |
Sulu, E. and 2011 [36] | Turkey | To investigate patterns of delays among patients with non-small-cell lung cancer and to identify reasons for the delays. | Prospective study | 101 | 60.6 years | 90.1% | 9.9% | Low index of suspicion for lung cancer, organizational problems, long waiting lists for radiotherapy and surgery, low performance of diagnostic methods and limited | Prehospital delays are largely dependent on the level of patient education and complex socioeconomic factors. |
Valdes, S. and 2010 [37] | Cuba | To identify the length of diagnostic delay in a group of patients diagnosed with non-small cell lung cancer by determining the time elapsed from onset of symptoms to confirmation of diagnosis. | Descriptive observational study | 96 | 32–88 years | 69.0% | 31.0% | Delays in obtaining results of CT tests, low index of suspicion for lung cancer and unavailability of diagnostic tools. | The length of health system-attributed diagnostic delay was prolonged and in need of improvement. |
Yurdakul, Ahmet Selim and 2015 [38] | Turkey | To investigate patient and doctor delays in the diagnosis and treatment of NSCLC and the factors affecting these delays. | Prospective study | 1016 | 61.5 years | 91.0% | 8.9% | Physician’s opinion of another diagnosis, delays in pathologic/radiologic/bronchoscopic examination, patient refusal to undergo procedure, a large volume of patients/lack of bed and long waiting time for hospitalisation. | Diagnostic and treatment delays were longer in early-stage cases. |
Zivkovic, D. and 2014 [39] | Montenegro | To investigate whether waiting times and delays in diagnosis and treatment of patients with lung carcinoma have any bearing on prognosis and survival. | Retrospective study | 206 | 66 years | 83.0% | 17.0% | Specialist services delay. | No significant difference in survival between patients with stage I and stage II NSCLC according to delay from the onset of first symptoms. |