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Table 2 Available evidence on Option B+, by year

From: UNICEF’s contribution to the adoption and implementation of option B+ for preventing mother-to-child transmission of HIV: a policy analysis

Year Description of study Description of study Data on Option B+ effectiveness and costs
2011 Country-level report [87] Quarterly summaries of PMTCT programme data in Malawi Change in coverage of PMTCT and ART services for pregnant women in Malawi following introduction of Option B+
2012 Country-level reports [87] Quarterly summaries of PMTCT programme data in Malawi Further data on change in coverage of PMTCT and ART services for pregnant women in Malawi following introduction of Option B+
International organisations document [54] Cost effectiveness analysis (Business case) Estimates of effectiveness and costs of Option B+ based on assumptions, not data
Journal article [88] Cost effectiveness modelling of individual countries Estimates of effectiveness and costs of Option B+ based on assumptions, not data
2013 Evaluation report [76] Evaluation of PMTCT programmes in Lesotho, Malawi, Tanzania and Zambia (10 facilities per country) Comparison of ART coverage in HIV-infected pregnant women and PMTCT cascade assessment, comparing Option B+ programme in Malawi with other countries
Journal article [36] Before and after study Number of pregnant women starting ART in Malawi and proportion receiving ART at 12 months, before and after Option B+
Journal articles [89, 90] Cost effectiveness modelling for individual countries Estimates of effectiveness and costs of Option B+ based on assumptions, not data
2014 Journal articles [91, 92] Retention of pregnant women in ART long-term Proportion of pregnant women who initiate ART in Option B+ services retained in care
Evaluation report [40] Programme evaluation Trends over time in PMTCT programme effectiveness in Malawi and barriers to Option B+
Journal articles [93, 94] Cost-effectiveness modelling of individual countries[9] and across regions Estimates of effectiveness and costs of Option B+ based on assumptions, not data
2015 Journal articles [95, 96] Effectiveness of Option B+ programmes for women and children Proportion of pregnant women who initiate ART in Option B+ services retained in care and MTCT rates
Journal article [76] Costs of switching from Option B to Option B+ Estimates of effectiveness and costs of Option B+ based on assumptions, not data
Journal article [97] Randomised controlled trial Demonstrated benefits of starting ART in all HIV-infected adults, regardless of CD4 count