Table 2 Global data of countries affected by NTDs, drugs donated, burden of each disease, and number of patent families
From: Patent landscape of neglected tropical diseases: an analysis of worldwide patent families
Neglected Tropical Diseases (PCT/IDM) | Number of countries | Disease burden | Preventive Chemotherapy/Intensified disease management | Effectiveness of current interventions | Total granted/patent families | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Incidence | Prevalence | DALYS | Prevention | Treatment | Resistance | Donated | Prevention | Treatment | |||
Human African trypanosomiasis (IDM) | 13 | 7,013 | 10,687 | 202,400 | Vector control and effective disease surveillance. | Pentamidine and Suramin (First stage treatment) | Yes [33] | No | Low | High | 41/198 |
Leishmaniasis (IDM) | 10 | 1,051,824 | 3,859,307 | 3,859,307 | Vector control and effective disease surveillance. Social mobilization and strengthening partnerships. | Amphotericin B, Miltefosine, fluconazole, itraconazole | Yes [34] | No | Low | High/Low | 740/2652 |
Leprosy(PCT) | 136 | 57,405 | 514,203 | 31,000 | BCG Vaccination | Multidrug therapy | Yes [35] | No | Low | High | 522/2206 |
Lymphatic filariasis (PCT) | 73 | No data | 38,464,150 | 2,075,000 | Albendazole through MDA programs. Mosquito control is a supplemental strategy supported by WHO. | Albendazole with either ivemectin or diethylcarbamazine | Yes [36] | Yes | High | High | 69/287 |
Onchocerciasis (PCT) | 31 | No data | 15,531,530 | 1,135,700 | Ivermectin through MDA programs. Vector control. | Ivermectin | Yes [37] | Yes | High | High | 88/313 |
Rabies | 150 | 18,312 | 704 | 931,600 | Integrated bite case management, Preventive immunization (vaccination) | Post-exposure prophylaxis, Integrated bite case management | No | No | High | High | 569/2694 |
Schistosomiasis (PCT) | 78 | No data | 252,339,520 | 2,613,300 | Praziquantel through MDA programs. Additionally, access to safe water, improved sanitation, hygiene education, and snail control. | Praziquantel | Yes [38] | Yes | High | High | 321/1722 |
Soil-transmitted helminthes (PCT) | 118 | No data | 761,893,771 | 3,378,300 | Albendazole/Mebendazole through MDA programs. Health education and improvement in personal hygiene are essential components of prevention. | Albendazole/Mebendazole | Probably [39] | No | High | High | 83/584 |