Table 4 Factors associated with LMC authorship in oncology RCTs
Univariate logistic regression | Multivariable logistic regression | |||
|---|---|---|---|---|
Variable | OR (95% CI) | p-value | OR (95% CI) | p-value |
Year | ||||
For every 1-year increase | 1.11 (1.02 – 1.20) | 0.01 | 1.12 (1.02 – 1.24) | 0.02 |
Site | ||||
Lung | 1.00 | Referent | 1.00 | Referent |
Breast | 1.38 (0.82 – 2.33) | 0.22 | 1.34 (0.70 – 2.56) | 0.38 |
Liver/colorectal/stomach | 0.66 (0.34 – 1.27) | 0.21 | 0.52 (0.24 – 1.10) | 0.09 |
Funding | ||||
Not for profit/Mixed | 1.00 | Referent | 1.00 | Referent |
Industry | 3.63 (2.00 – 6.58) | <.0001 | 3.54 (1.85 – 6.78) | 0.0001 |
Not specified | 0.88 (0.44 – 1.79) | 0.73 | 0.95 (0.45 - 2.03) | 0.90 |
Multi-center | ||||
No | 1.00 | Referent | 1.00 | Referent |
Yes | 1.24 (0.77 – 2.00) | 0.38 | 0.91 (0.52 – 1.58) | 0.74 |
Placebo-controlled | ||||
No | 1.00 | Referent | 1.00 | Referent |
Yes | 3.08 (1.57 – 6.07) | 0.001 | 2.57 (1.19 – 5.54) | 0.02 |
Treatment type | ||||
Basic/Limited | 1.00 | Referent | 1.00 | Referent |
Enhanced/Maximal | 1.11 (0.68 – 1.82) | 0.68 | 0.61 (0.32 – 1.16) | 0.13 |
Treatment aim | ||||
Adjuvant | 1.00 | Referent | 1.00 | Referent |
Both | 3.67 (1.48 – 9.06) | 0.005 | 5.12 (1.81 – 14.48) | 0.002 |
Metastatic | 3.38 (1.75 – 6.55) | 0.0003 | 4.00 (1.90 – 8.43) | 0.0003 |
Supportive measures | 2.67 (0.91 – 7.79) | 0.07 | 1.21 (0.35 – 4.17) | 0.76 |
Design | ||||
Factorial/multiple arms | 1.00 | Referent | 1.00 | Referent |
Simple 2 arm | 0.96 (0.49 – 1.90) | 0.91 | 0.73 (0.34 – 1.58) | 0.43 |
Ethics | ||||
Not documented | 1.00 | Referent | 1.00 | Referent |
Documented | 1.36 (0.73 – 2.54) | 0.33 | 0.76 (0.37 – 1.56) | 0.45 |