Table 1 Summary of key changes in South African PMTCT guidelines
From: Patient factors to target for elimination of mother-to-child transmission of HIV
Date | PMTCT guidelines |
|---|---|
2002 to February 2008 | Only intrapartum and infant sdNVP available for prophylaxis |
2004 | ART became available; CD4 threshold for ART initiation 200 cells/mm3 |
February 2008 | Maternal AZT (from 28Â weeks gestation) and infant AZT, for prophylaxis. One to four weeks of infant AZT, depending on duration of maternal prophylaxis or treatment |
April 2010 | Gestational age for AZT initiation reduced to 14 weeks, CD4 threshold for ART initiation increased to 350 cells/mm3, Infant NVP syrup prophylaxis introduced for breastfeeding period – six weeks if preconception initiation of maternal ART; extended to cover breastfeeding period if no maternal ART |
April 2012 | Withdrawal of free infant formula, EFV-based ART regimen approved for pregnant women |
April 2013 | EFV-based FDCs for prophylaxis and treatment introduced |