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Table 1 Leading causes of premature mortality, disability and disease burden, World, 1990

From: The evolution of the Global Burden of Disease framework for disease, injury and risk factor quantification: developing the evidence base for national, regional and global public health action

Premature Mortality

Disability

Disease Burden

Rank

Disease/ injury

YLLs (000s)

Cumulative %

Disease/injury

YLDs (000s)

Cumulative%

Disease/injury

DALYs (000s)

% of Total

1

Lower res. inf.

108601

12.0

Depression

50810

10.7

Lower res. inf.

112898

8.2

2

Diarrhoeal dis.

94434

22.4

Iron def. anaem.

21987

15.4

Diarrhoeal dis.

99633

7.2

3

Perinatal cond.

82681

31.5

Falls

21949

20.0

Perinatal cond.

92313

6.7

4

Isch. heart dis.

41595

36.1

Alcohol use

15770

23.4

Depression

50810

3.7

5

Measles

36450

40.1

COPD1

14692

26.5

Isch. heart dis.

46699

3.4

6

Tuberculosis

34304

43.9

Bipolar dis.

14141

29.5

Cerebrovas. dis.

38523

2.8

7

Cerebrovas. Dis.

32115

47.5

Congenital anom

13507

32.3

Tuberculosis

38426

2.8

8

Malaria

28038

50.5

Osteoarthritis

13275

35.1

Measles

36520

2.7

9

Road traffic acc.

26162

53.4

Schizophrenia

12183

37.7

Road traffic acc.

34317

2.5

10

Congenital anom.

19414

55.6

Obs.-comp dis2

10213

39.9

Congenital anom.

32921

2.4

  1. Source Murray and Lopez (10)
  2. 1 Chronic obstructive pulmonary disease
  3. 2 Obsessive-compulsive disorders