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Table 1 Leading causes of premature mortality, disability and disease burden, World, 1990

From: The evolution of the Global Burden of Disease framework for disease, injury and risk factor quantification: developing the evidence base for national, regional and global public health action

Premature Mortality Disability Disease Burden
Rank Disease/ injury YLLs (000s) Cumulative % Disease/injury YLDs (000s) Cumulative% Disease/injury DALYs (000s) % of Total
1 Lower res. inf. 108601 12.0 Depression 50810 10.7 Lower res. inf. 112898 8.2
2 Diarrhoeal dis. 94434 22.4 Iron def. anaem. 21987 15.4 Diarrhoeal dis. 99633 7.2
3 Perinatal cond. 82681 31.5 Falls 21949 20.0 Perinatal cond. 92313 6.7
4 Isch. heart dis. 41595 36.1 Alcohol use 15770 23.4 Depression 50810 3.7
5 Measles 36450 40.1 COPD1 14692 26.5 Isch. heart dis. 46699 3.4
6 Tuberculosis 34304 43.9 Bipolar dis. 14141 29.5 Cerebrovas. dis. 38523 2.8
7 Cerebrovas. Dis. 32115 47.5 Congenital anom 13507 32.3 Tuberculosis 38426 2.8
8 Malaria 28038 50.5 Osteoarthritis 13275 35.1 Measles 36520 2.7
9 Road traffic acc. 26162 53.4 Schizophrenia 12183 37.7 Road traffic acc. 34317 2.5
10 Congenital anom. 19414 55.6 Obs.-comp dis2 10213 39.9 Congenital anom. 32921 2.4
  1. Source Murray and Lopez (10)
  2. 1 Chronic obstructive pulmonary disease
  3. 2 Obsessive-compulsive disorders
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